You can disable the Sense UI without uninstalling. Go to the "manage application" list of apps, open the TouchFlo, press "Clear defaults" and "Force stop". Next time you press the home button a dialog will appear asking whtat to use as your desktop app - "TouchFlo" or "Home" (the classic android desktop).

OK, I've decided to make it happen. I've disabled the Sense UI on my HTC Hero to see if it will speed it up and make dealing with the actual phone (by which I mean the "talkie" part, which has been a bit jittery recently) a little better. I've updated K-9 Mail, the Facebook app, etc. So far, obviously it's a little less "slick" and (to be fair) I've got fewer widgets running (crossing fingers for battery life). It does seem a touch snappier so far, and it's kinda fun to have what feels like a new phone.